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Home NEWS Scientific study of the disease Mesothelioma asbestos Cancer

Scientific study of the disease Mesothelioma asbestos Cancer

Mesothelioma asbestos Cancer - a malignant (more) tumor that grows from the mesothelial tissue with areas of sarcomatoid spindle-shaped cells and adenomatous tissue. Typically, the tumor is found in the pleura and peritoneum, at least - in the testis and joints. It grows as a thick layer covering the internal organs, and is composed of spindle-shaped cells and fibrous tissue.

Risk factors: prolonged exposure to asbestos, smoking.

Classification

  • · Benign Mesothelioma asbestos Cancer - Mesothelioma nonmetastasizing as a node on a stem or a broad base
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• Clinical features: dyspnea (associated with exudative pleurisy), chest pain (due to tumor invasion into intercostal space), cough and hemoptysis, weight loss. Diagnosis: radiography of the chest, pleural puncture, evacuation and effusion cytology, biopsy and thoracoscopy.

• TNM-classification (applies only to tumors of the pleural cavity, see also tumor stage)

• • Tx - insufficient data to assess the primary tumor

• • T0 - the primary tumor is not determined

• • T1 - Tumor limited to the parietal and / or visceral pleura one side

• • T2 - the tumor grows on the affected side: lung, hilar fascia, diaphragm, pericardium

• • T3 - tumor grows on the side of destruction: the muscles of the chest wall, ribs, mediastinum

• • T4 - Tumor directly invades any of the following structures: reverse lung, pleura on the opposite side, the peritoneum, the abdominal organs, tissues of the neck

• • N0 - no metastases in regional lymph nodes

• • N1 - Metastasis in peribronchial and / or hilar lymph nodes on the affected side, including direct germination

• • N2 - metastases to mediastinal lymph nodes on the affected side and / or bifurcation (subkarinalnye)

• • N3 - metastasis to lymph nodes or mediastinal root of the lung on the opposite side; preskalennye or supraclavicular (either side).

• Grouping by stage

• Stage I: T1-2N0M0

• Stage II: T1-2N1M0

• Phase III

• • T1-3N2M0

• • T3N0-2M0

• Phase IV

• • T1-3N3M0

• • T4N0-3M0

• • T1-4N0- 3M1.

• Treatment

• Radical treatment is possible only with the surgical removal of limited forms of mesothelioma, which is rarely possible to perform operations

• The volume can range from excision of the tumor of the pleura with the underlying tissues to plevropulmonektomii, which, however, does not improve long-term outcomes

• The primary treatment for most patients - chemotherapy different combinations of drugs with the use of platinum (not developed standard procedures), including intrapleural administration. Pleural puncture or installation mikrodrenazha

• thiotepa 20 mg in 6.8 mL of 0.9% sodium chloride intraplevralno 01.02 p / week

• • pleurodesis: thoracoscopy with talcum powder or spray treatment with tetracycline in order to obliterate the pleural cavity

• Radiotherapy characterized by low efficiency.

• The prognosis is poor, the tumor is growing quickly, early spread to mediastinal lymph nodes.

Localized fibrous mesothelioma (solitary fibrous tumor) is formed mainly from the visceral pleura. Most of these tumors are benign, that defines a completely favorable prognosis • Clinical features: chest discomfort, dyspnea, pulmonary hypertrophic osteoarthropathy syndrome with arthralgia of the hands, elbows and knees, "drumsticks" (developed later) • Treatment: resection of the tumor, symptomatic treatment of hypertrophic pulmonary arthropathy.

Peritoneal mesothelioma asbestos Cancer occurs most often in men over 50 years old and is usually associated with asbestos exposure and appears enlarged abdomen, abdominal pain, nausea, vomiting and weight loss

• Diagnosis is established the detection of malignant cells in the exudate and biopsy specimens obtained during paracentesis, biopsies or laparotomy

• Treatment of localized forms of mesothelioma is that it is a radical surgical removal, in diffuse forms of surgical treatment is not indicated, use radiation or chemotherapy, or a combination, therapy is seldom effective.

Testicular mesothelioma asbestos Cancer (adenoma testicular adenofibroma testicle, testicular tumor adenomatous) - mesothelioma originating from the serous membrane of the testis, epididymis and its spermatic cord, characterized by a benign growth with the emergence ferum cavities.

Mesothelioma asbestos Cancer joint (Sinovioma, endotelioma synovial) - a tumor originating from the cells of the synovial tendon sheaths or mucous bags

• Sinovioma benign (giant tumor of tendon sheath, gigantoma tendon Sinovioma giant, Sinovioma ksantomatoznaya, sinovioendotelioma, tenosynovitis nodose) - a benign tumor of the tendon sheath (usually thumb), consisting of fibroblasts and giant cells

•Sinovioma malignant (synovial sarcoma, synovial sarkoendotelioma, sinovialoma malignant) based on the elements of the tendon sheaths, joints and mucous bags.

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