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Saturday, 15 September 2012 14:35

What you need to know about cancer?


In the XX century, the cancer is called "disease of the century", and in the XXI is probable that he will be the first scourge of mankind. Grim realities of today - each year from cancer worldwide are killed about seven million people. But even that terrible figure will not limit: by The World Health Organization, approximately 2020 cancer will take the leading position among the causes of death, which will allow him to overtake cardiovascular system.

Bodies, most predisposed to cancer

Scientists argue that the frequency of lesions of various human organs cancer - is different. As for the men, most often (about 50% of all cases of canser), they are defeated the digestive system, then the frequency goes: respiratory organs, skin, mouth, lower lip and throat. In the ladies cancer often affects the uterus, then - the digestive organs, breast, and skin.

Cancer of the digestive system begins with the deterioration of swallowing function, at first only during swallowing coarse food, and in the future, depending on the degree of tumor growth and narrowing of the lumen of the start even when consuming liquid food. Sometimes the pain can be felt in the chest and epigastria region.

Breast cancer (breast cancer) characterized by different forms, but most often it is represented by a solid painless tumor, which is located in the interior of the breast. In most cases, women find it yourself, it is absolutely random. Quite often, it is preceded by little lumpy breasts. If you find something like that, see your doctor as soon as possible!

Cancer of the lower lip begins to develop on the site of a variety of diseases lips - non-healing sores and cracks, stains, and other processes that are associated with the growth of tissue. As practice shows, these sores can be covered crust, simulating the process of healing, but it soon disappears, and ulcers will continue to harden and grow. In order to prevent the formation of cancers in organic diseases of the lower lip as quickly as possible to stop smoking because smoking only assists in the development of malignant tumors.

Uterine cancer, as you might guess from the name, is striking in the first place, the cervix. Its development occurs against a variety of chronic processes (erosion, polyps, etc.). Quite often the cause of this disease is unliquidated damages, which are caused by abortion or childbirth. At the initial stage of cancer of the uterus does not have any external manifestations? They occur only when the tumor starts increasing. This disease is accompanied by a disturbance of menstruation, pain, bleeding. Doctors say that the pain - is one of the last signs, signaling an advanced stage of the disease.

As for colon cancer, it may appear on the background of polyps located in the rectum. His most "popular" is a sign of bleeding, but it appears very late - at a time when the tumor was large development and began to disintegrate. Such bleeding is sometimes confused with hemorrhoids, respectively, the disease starts. It should be noted that the hemorrhoid is not premalignant disease, but they are quite capable of existing together.

Lung cancer or mesothelioma asbestos cancer is beginning to dry cough in the morning and later at night. With the development of tumors, coughing will generate a significant amount of sputum, which has a slimy character. In some cases, there is pain in the chest, which intensified during coughing, shortness of breath and a recurring slight temperature increase, in rare situations - hemoptysis. Please note that a major role in the development of lung cancer is smoking regularly.

Stomach cancer often occurs as a result of suffering a prolonged illness of the stomach - ulcers, polyps, and various forms of gastritis. The primary symptoms are slightly: blanching of the skin, fatigue, weight loss. Later formed an aversion to meat food, begins nausea, vomiting and lost appetite. If the tumor was a good development, periodically may appear painful. It should be noted that the risk of cancer is characterized by the direct dependence of hereditary predisposition.

Stage for cancer

This terrible disease has several stages of development. Depending on what stage the cancer that will take appropriate actions to further diagnosis and treatment. Cancer is characterized by four stages (I, II, III and IV). If there is a small, limited places cancer, then it is about I-th stage of the cancer, and also a lot of advanced metastatic disease, we can talk about cancer IV-th stage.

Depending on the variety of diseases are assigned specific treatment techniques. In the first research professionals only define the clinical picture of the cancer. In the future it is determined whether the cancer can be removed.

Staging, that is the definition of the spread in the human body of the cancer process, is considered the most important event, necessary to select the method of treatment. We should not forget that the process of cancer development may take several years or even decades. During this period, pre-cancerous cells, where under the influence of carcinogens, made genetic changes (mutations), to become more viable and active. In the future, they form something like tumorlet which are clusters of malignant tissue, is not harassing people, and they are almost impossible to diagnose. As a result, tissue grows vessels that feed them, and these tumorlet turns into a malignant tumor of the final stages of development.

Thursday, 06 September 2012 11:04

Mesothelioma asbestos cancer

 

Mesothelioma or asbestos cancer - a form of cancer, which is characterized by the fact that cancer cells are placed in a membrane envelope. Membrane - mezotelium, consists of two layers. Mezotelium produces lubricating fluid, through which bodies are moved safely, such a beating heart.
Mesothelioma asbestos cancer - a disease in which the mezoteliuma cells are abnormal and begin to divide. Modified cells can invade organs and connective tissues, damaging them. Cancer cells often spread to other parts of the body. The disease usually begins in the chest, and then progresses and affects other parts of the body. Major risk factor for the disease is contact with asbestos. The danger is that the pathology is not immediate, but after 30-50 years.
The disease is characterized by low average survival of patients, only 1-2 years. If the disease is detected at later stages, the prognosis is extremely unfavorable. Early symptoms of Mesothelioma asbestos cancer can easily be confused with symptoms of other diseases. Primary symptoms in most patients appear for 2-3 months before detection of the tumor. Asbestos cancer can have some basic varieties: pleural, pericardial, vaginal, and benign mesothelioma of the peritoneum.
· Symptoms of Mesothelioma asbestos cancer
· Symptoms vary depending on the type of mesothelioma. For example, patients with pleural mesothelioma asbestos cancer complain of pain in the chest on the side and the back. Many patients experience shortness of breath. Some cases are characterized by shortness of breath, coughing, sweating, weakness and fever. Other symptoms include: hoarseness, facial swelling, hemoptysis. Peritoneal mesothelioma patients complain of abdominal pain, nausea and vomiting. In some patients, fluid can build up in the abdomen - ascites.
· Aftermath
The main danger of the disease is that the abnormal cells may be spaced throughout the body. There are three main pathways of tumor cells in the human body. Tumor cells through the blood or lymphatic system may spread throughout the body, the result - the formation of secondary tumors. The process of separation of tumor cells is called metastasis. The primary tumor and secondary education are to cancer of the same species. Depending on what stage the disease, mesothelioma asbestos cancer is conventionally divided into two groups. The localized mesothelioma is characterized by the fact that cancer cells are located exclusively in the inner layer of the chest wall in the tissues covering the lungs, diaphragm, and in the bag, which covers the heart, with the same party. To include common mesothelioma disease II, III, IV stage. In the pathological process may also be involved lymph nodes that are on the other side of the chest or even beyond.
· One of the negative effects of mesothelioma is a relapse. Relapse - repeatedly arisen disease after the patient has already been covered treatment. Education may recur in the pleural area or in a new place.
· Treatment and complications
· There are several diagnostic techniques that enable the diagnosis and confirm it. To detect tumors using: X-ray, computed tomography, magnetic resonance imaging, thoracoscopy, laparoscopy.
· To date, identify several basic methods of treatment of mesothelioma asbestos cancer. It should be noted that the standard methods used, so the methods that are currently in clinical trials. The essence of the clinical trials - the improvement of existing therapies, data on new treatments. The possibility of patient participation in clinical trials is discussed with your doctor. The standard method of treatment include: surgical way, radiation and chemotherapy.
· Surgical method involves removal of the tumor by surgery. Even if the doctor removes the visible part of the tumor, the patient will still prescribe postoperative chemotherapy and radiation therapy. This is done in order to completely remove the abnormal cells.
· Radiation therapy is a method of treatment using high-frequency X-ray. This approach allows you to completely remove the cancer cells, slowing tumor growth. Radiation therapy may be of two types: external and internal. External radiation therapy of mesothelioma asbestos cancer involves the direction of the unit, located next to the patient directly to the tumor. Internal therapy suggests that radioactive substances are inserted near the tumor or in the tumor itself. The method of radiation therapy is chosen depending on the stage and type of cancer.
Chemotherapy involves the use of cytotoxic drugs, their action is directed at the destruction of cancer cells, slowing the malignant process. Chemotherapy drugs can be taken orally, intravenously. Drug enters the bloodstream and spreads throughout the body, destroying the tumor cells. If the chemical agent is injected directly into the affected area, such as the peritoneum, such a therapy called regional. Combination chemotherapy involves the use of several drugs. The route of administration is chosen depending on the type and stage of the cancer being treated.
Today, there is the search for new treatments. Information about them is distributed by the National Cancer Institute, as all the necessary information about the programs and opportunities for participation in it can be obtained from your doctor. The success of disease control is correct and timely diagnosis, prescription of adequate and effective treatment.

 

Thursday, 06 September 2012 11:03

What is peritoneal mesothelioma


What triggers mesothelioma of the peritoneum

Pathogenesis (what's going on?) During peritoneal mesothelioma

Symptoms of peritoneal mesothelioma asbestos cancer

Diagnosis of peritoneal mesothelioma

Treatment of peritoneal mesothelioma

Prevention of peritoneal mesothelioma

Which doctors should contact if you have peritoneal mesothelioma

What is peritoneal mesothelioma asbestos cancer:

For prolonged inhalation of asbestos vapors can affect different organs including the peritoneum, which causes mesothelioma peritoneum.

Peritoneal mesothelioma, occurs more frequently in men over 50 years old.

What triggers peritoneal mesothelioma:

Peritoneal mesothelioma is caused by exposure to asbestos body vapors.

Pathogenesis (what's going on?) During peritoneal mesothelioma:

Peritoneal mesothelioma asbestos cancer can grow as a node in a part of the visceral or parietal peritoneum (nodular form) or more diffusely distributed peritoneum, infiltrating it, like sheath enveloping internal organs (diffuse form). If the cavity of the abdomen remains free, then it is observed accumulation of sero-fibrinous or hemorrhagic exudates.

Histologically, the tumor usually has the structure of a solid adenocarcinoma or cancer. In addition, the isolated fibrous, tubular, and mixed form of pleural mesothelioma. Malignant mesothelioma metastasize to regional lymph nodes (96.5%), and other lung and pleura (75%), the pericardium. Hematogenous metastases occur much less frequently.

Symptoms of peritoneal mesothelioma:

The clinical picture of the initial stages of peritoneal mesothelioma asbestos cancer is very fuzzy. The symptoms appear when there is a malfunction of the abdomen as a result of growing into their tumor. The first complaint with mesothelioma of the peritoneum reduced to discomfort and abdominal pain without clear localization, nausea, sometimes poor appetite, alternating diarrhea and constipation. Gradually accumulates in the abdominal cavity fluid with plenty of protein, but not always, containing tumor cells. When a localized form of mesothelioma of the peritoneum in the abdomen may be palpable movable tumor.

Diagnosis of peritoneal mesothelioma:

Diagnosis is the detection of malignant cells in the exudate and biopsy specimens obtained during paracentesis, biopsies or laparotomy.

Treatment of peritoneal mesothelioma:

Treatment of localized forms of mesothelioma, we lay in its radical surgical removal, in diffuse forms of surgical treatment is not indicated, use radiation or chemotherapy, or a combination, therapy is seldom effective.

Prevention of peritoneal mesothelioma:

For prophylaxis (prevention) of mesothelioma asbestos cancer should avoid contact with asbestos at home and at work.

Thursday, 06 September 2012 10:57

Brief description of the disease Mesothelioma

 

Mesothelioma asbestos cancer - it is extremely dangerous type of tumor, characterized by interstitial lung pleura and peritoneum. This tumor is formed mesothelium - the epithelial tissue that lines the surface of the body cavities.
Mesothelioma does not spare neither adults nor children, the swelling can occur even in the 2-year-old kid.
And the risk of disease in men by almost 8 times higher than in women. This is due to several reasons.

Causes of Mesothelioma asbestos cancer

The main cause of cancer - mesothelioma - is long and intensive engagement with asbestos. As you know, asbestos - a building material, a mixture of fiberglass and plaster. Inhalation of asbestos dust can directly cause cancer. Asbestos fibers actively affect the lining of the airways, getting all of them deeper into the pleura. The accumulation of these fibers causes mesothelioma - a professional disease of builders. Smoking aggravates the situation, while not being the main cause of Mesothelioma asbestos cancer.
There are also cases when a genetic predisposition has become a major factor in the development of mesothelioma.

Symptoms of  Mesothelioma asbestos cancer

Early symptoms of pleural mesothelioma include: pain in the chest, weakness, difficulty breathing, dry cough - and many others, the neglect of which will lead to irreversible consequences.
Mesothelioma of the peritoneum, as a rule, it is severe abdominal pain, weakness, vomiting, and weight loss. Few people care about these symptoms: some mistake them for symptoms of poisoning, others openly ignore. Remember that mesothelioma "wait" and will not reveal in 2-3 - months, when the symptoms will show activity: pain increased, and the general condition deteriorates. Since it's still cancer - cancer treatment effective in the early stages.
The fact is that as with any cancer, the peritoneal Mesothelioma asbestos cancer is under development. In the first stage the patient is affected pleura of the lung, lymph nodes at the same time while intact. Peritoneal mesothelioma is the second stage has been a relatively large "field of activity": it extends to the diaphragm. The third stage is characterized by lesions of the lymph nodes and the front of the chest wall. The fourth stage - the most dangerous - and integrated into the surrounding tissue and even carried through the bloodstream to more distant organs, thus affecting the entire body.

Diagnosis of Mesothelioma asbestos cancer

Diagnosis of mesothelioma can be done in different ways:
  • · X-rays will reveal pleural thickening, and the presence of fluid in the pleural cavity
  • · CT (computed tomography) to determine the stage of the tumor and help assign an effective treatment.
  • · With the help of an MRI (magnetic resonance imaging) has become possible to determine whether the diaphragm is intact mesothelioma.
  • · Thoracoscopy - endoscopic method for studying the pleural cavity. Manufactures special machines, reveals a tumor in its earliest stages. As a rule, the study takes a small piece of the pleura or pleural fluid. A similar method of investigation - laparoscopy - used for inspection of the abdominal cavity.
Treatment of Mesothelioma asbestos cancer

Mesothelioma treatment is usually carried out in several ways:
· Chemotherapy. Drugs prescribed for chemotherapy can be administered as an intravenous and intrapleural (or into the abdominal cavity in the treatment of peritoneal mesothelioma). Treatment of tumors with poisons and toxins effectively kills cancer cells, while not causing harm to human body strong.
· Radiation therapy or radiation therapy. Characterized as a highly effective, rapidly destroying the cells in the Mesothelioma asbestos cancer. He has a number of unpleasant side effects: burn tissue, shortness of breath, fatigue, hair loss.
· Surgical method. Mesothelioma Treatment by removal of the tumor / pleura is the most effective, however, not all patients with mesothelioma, it is shown. Only upon satisfactory general condition of the patient and the absence of other diseases permitted surgery. A complete removal of the tumor is possible only if the localized mesothelioma.

Other ways of treating Mesothelioma asbestos cancer.

For example, removal of fluid from the pleural cavity through a needle. After this procedure, there is improvement in the general condition of the patient, reducing the pain. However, over time fluid builds again, and repeats the procedure. Introduction of antibiotics into the pleural cavity also helps to reduce the amount of fluid and pain.
Once diagnosed with mesothelioma, the people, on average, do not live more than a year, with the average age of the cases - 65 years. Think about it and avoid any contact with the deadly substance in his youth, so you do not regret it in old age.

 

In the previous studies it has been hypothesized that low levels of the enzyme thymidylate synthase (TS) is probably seen in those patients for whom the drug pemetrexed help, but the results have been, at least, inconclusive and sometimes contradictory.
Studies in the University Cancer Center in Colorado and recently published in the publication Journal of Thoracic Oncology, give explanation: only in combination with a high level of the second enzyme, (folilpoliglyutamat synthetase) FPGS, low TC predicts the response to pemetrexed in patients with malignant pleural mesothelioma.
"There is hope that oncologists were able to check the patient's enzyme levels TS and FPGS and thus detect whether the patient treated pemetrexed or more appropriate to another treatment," - says first author, Daniel C. Christoph, MD Science, oncologist West Cancer Center, working postdoctoral as an international scholar and researcher in the laboratory researcher of the University of Colorado Cancer Center, MD Fred Hirsch.
Pemetrexed acts by inhibiting the enzyme TS, which requires cancer cells to replicate their DNA. Thus, it stands to reason that those tumors that have the level of TC is already low, the drug will have the greatest impact: the blocking of residual TC virtually stop the synthesis of new DNA of cancer cells.
At the same time, Christophe and his colleagues tested 84 cases of mesothelioma, in which patients were treated drug pemetrexed, and found that only the combination of low levels of TC with both high FPGS predicts patient's response to the drug.
The study was also able to explain the mechanism by which FPGS pemetrexed improves clinical effectiveness:
"High levels of FPGS allows pemetrexed stay longer inside the cell, allowing the drug to act against the vehicle in for a longer time" - continues to Christophe. Of the cases studied, patients with low TS and high FPGS increasingly respond to treatment with pemetrexed and their life expectancy was longer after treatment.
According to Kristof, the current study is the material preclinical work necessary to confirm the results of the study predicting the effectiveness of the TS and FPGS impact on patients with mesothelioma. Further research and monitoring of the data of these biological markers may allow their wide use in predicting the effectiveness of treatment of patients drug pemetrexed.

Thursday, 30 August 2012 23:49

What is asbestos mesothelioma.

Mesothelioma (mesothelioma) - a rare form of cancer - a tumor of mesothelial tissue (one type of epithelium). More information about the disease will tell the Soviet Union.Epithelium - the tissue that lines the surfaces and cavities of the body, mucous membranes, internal organs, respiratory system, digestive tract, urinary ways and forms a large part of the iron in the body. The epithelium is divided into different types of origin, structure, and functions.
One type of epithelium - is mesothelioma. He lines the serous membrane, ie, the peritoneum, pleura and lung, pericardium (pericardial sac), etc. Consequently, mesothelioma - a tumor that grows from the mesothelial tissue and affects the serous membranes. Mesothelioma can be benign or malignant (the latter is more common).
Mesothelioma - a rapidly growing aggressive tumor that metastasizes early, treating it rather difficult, especially if you have been diagnosed late. The median survival of patients is 1-2 years.

Mesothelioma is most common lung pleura and peritoneum, at least - of the testicles, joints, pericardium. Among the risk factors that increase the risk of mesothelioma include prolonged exposure to asbestos, especially in combination with smoking. This swelling can sometimes be asymptomatic, but if symptoms do occur, at an early stage can not be considered specific, why mesothelioma is difficult to diagnose. Often it is detected at a late stage, hence the low survival rate of patients with mesothelioma.

Pleural mesothelioma is usually manifested in pain at the bottom of the chest at the back or the side surface, shortness of breath, hoarseness, coughing up blood, swelling of the face and upper extremities, in some cases, may experience difficulty swallowing, cough, weight loss, weakness, sweating, fever (low-grade, but constant). One of the most common symptoms - effusion (fluid in the pleural cavity).

Peritoneal mesothelioma usually has the following symptoms: abdominal pain, nausea, vomiting, weight loss, enlarged abdomen. Some patients have ascites - fluid in the peritoneal cavity. Usually this type of cancer occurs in men over 50.
There are several treatments for malignant mesothelioma. If the patient is in good condition, and the tumor is localized, the possibility of radical surgery, ie, the complete removal of the tumor. If the patient's heavy, and the swelling is extensive, can perform palliative surgery - operation to eliminate or reduce the discomfort caused by tumor growth.

However, as we have said, mesothelioma is often diagnosed at a late stage, when major surgery is impossible to produce because of the serious condition of the patient. In such cases, radiation therapy may be used as the primary method of treatment. Also, after the non-radical operations can be assigned a radiation therapy to kill any remaining cancer cells. And for investment due to the growth of tumors symptoms (shortness of breath, difficulty swallowing, pain, bleeding) use palliative radiation.
Another method of treatment of mesothelioma - chemotherapy, the drugs can enter not only intravenously, but the pleural or peritoneal cavity (depending on whether a tumor - mesothelioma of the pleura or peritoneum mesothelioma). Chemotherapy can be as basic or secondary treatment for cancer (depending on what stage the mesothelioma), but keep in mind that this method of treatment provides only a temporary effect and is used as a palliative.

Despite the fact that mesothelioma - a rare type of tumor that is no reason to neglect their health. Do not ignore any of the warning signs, it's better to be safe than to lose valuable time. There have been cases where the symptoms of mesothelioma took for chronic bronchitis or  smoker's cough , and when they put the correct diagnosis, it was too late. And if you are at risk (in contact with asbestos or production), do not forget about regular checkups with your doctor.

Wednesday, 29 August 2012 00:59

Mesothelioma settlement amounts

These main types of malignant mesothelioma tend to be epithelioid, sarcomatoid as well as mixed / biphasic. Epithelioid one of the general form, since approximately 50-70% of the most reported cases of mesothelioma is usually the view. Epithelioid also offers the best tactical differences. This has an effect on the internal organs and internal treatment floors. Sarcomatoid a much more serious problem, because it has the effect of additional tissue in your body such as the material of cartilage, muscle groups, bone tissue and also fat. However, this particular cancer is much rarer, as it just happens 7-20% of that time period. Mixed / biphasic has equally generated from cancer at the same time, which is 20-35% of the situations.
asbestos settlement occurs within the assembly relative to mineral precipitation in the environment. This provides a remarkable resistance to high temperature. Before many market sectors used asbestos settlement on a huge amount, because it is effective and also robust. This is a study that 80% of cases result from the settlement experience of asbestos. This type of mineral, when exposed to temperatures leaves behind, invade environment. Fiber as a special layer of fabric attached regarding bronchial begin development associated with malignant tissue.
At present, these types of asbestos settlement ends a condition for which is incurable, but because of the amount of attention the disease gets a lot of top scientists and researchers are also all over the world will work to develop an end to the disease. Just like numerous cancer, not continuing assistance as well as attention, research, and the funding is not possible.
For your case is also vital that you provide all of your medical records relating to your mesothelioma prognosis and also the forecast. The more you can offer, the more far away and you and your circumstances are likely to be. This can help maintain the actual monetary award, which really deserves a man, as organizations asbestos settlement will often try to break free from the littlest settlement.
Normal treatment of the disease tends to be radiation therapy, surgery and also rays. It really is preferable to combine several treatment once and for all the results. The disease is identified delayed so many times, surgery can not be solved. With all the latest treatments, such as angiogenesis, gene drug as well as doctors immunotherapy wants to discover some ways to make the patient live longer.
The actual culprit in the city do not automatically fit people. In legal jargon particular defendant is more widely known as the "syndrome." Despite the fact that the great thing can really be the person most of the time it is - an organization, a company, or maybe organization.
Incredible as it might seem, it would be - because the dangers associated with the settlement of asbestos becomes identified earlier - back in the 50's, P. Lorillard Company used a deadly crocidolite fibers in its Kent e cigarette filter systems. The manual evaluation of the list of most craigs identification settle asbestos personal consultant writes about the background loaded asbestos settlement "mikronochnuyu" filter used on Kent tobacco between 1952 and also 1956. And Ough. Reports Web site of the Federal Government S., which anyone who has smoked cigarettes swab each day for Kent, smoking in between 1952 and 1957 may have faced a 131 million crocidolite construction year.
Mediastinum research Mediastinoscopy (area in the upper part of the body, made up of the heart, arteries excellent, lymph nodes, esophagus, nervousness, and so on). Mediastinoscopy can try the lymph nodes in your body to find metastases.
Pathological examination biopsy samples under study is a microscopic lense - the difficulty to identify mesothelioma at some point. Cellular structure of the tumor can be viewed many different types. These types of fabrics may seem similar, along with another cancer. Peritoneal cells may well seem like pleural mesothelioma, or even additional types of lung cancer and also ovarian cancer. Epithelioid type of mesothelioma is much more frequent and better assessed on the treatment of more than aggressive sarcomatous appearance. Biphasic mesothelioma - a combination of each.
Asbestos settlement proposals publicity boiler manufacturer reduced considering the 70th by modifications in isolation and also shelled parts inspection.

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