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In the previous studies it has been hypothesized that low levels of the enzyme thymidylate synthase (TS) is probably seen in those patients for whom the drug pemetrexed help, but the results have been, at least, inconclusive and sometimes contradictory.
Studies in the University Cancer Center in Colorado and recently published in the publication Journal of Thoracic Oncology, give explanation: only in combination with a high level of the second enzyme, (folilpoliglyutamat synthetase) FPGS, low TC predicts the response to pemetrexed in patients with malignant pleural mesothelioma.
"There is hope that oncologists were able to check the patient's enzyme levels TS and FPGS and thus detect whether the patient treated pemetrexed or more appropriate to another treatment," - says first author, Daniel C. Christoph, MD Science, oncologist West Cancer Center, working postdoctoral as an international scholar and researcher in the laboratory researcher of the University of Colorado Cancer Center, MD Fred Hirsch.
Pemetrexed acts by inhibiting the enzyme TS, which requires cancer cells to replicate their DNA. Thus, it stands to reason that those tumors that have the level of TC is already low, the drug will have the greatest impact: the blocking of residual TC virtually stop the synthesis of new DNA of cancer cells.
At the same time, Christophe and his colleagues tested 84 cases of mesothelioma, in which patients were treated drug pemetrexed, and found that only the combination of low levels of TC with both high FPGS predicts patient's response to the drug.
The study was also able to explain the mechanism by which FPGS pemetrexed improves clinical effectiveness:
"High levels of FPGS allows pemetrexed stay longer inside the cell, allowing the drug to act against the vehicle in for a longer time" - continues to Christophe. Of the cases studied, patients with low TS and high FPGS increasingly respond to treatment with pemetrexed and their life expectancy was longer after treatment.
According to Kristof, the current study is the material preclinical work necessary to confirm the results of the study predicting the effectiveness of the TS and FPGS impact on patients with mesothelioma. Further research and monitoring of the data of these biological markers may allow their wide use in predicting the effectiveness of treatment of patients drug pemetrexed.

Thursday, 30 August 2012 23:49

What is asbestos mesothelioma.

Mesothelioma (mesothelioma) - a rare form of cancer - a tumor of mesothelial tissue (one type of epithelium). More information about the disease will tell the Soviet Union.Epithelium - the tissue that lines the surfaces and cavities of the body, mucous membranes, internal organs, respiratory system, digestive tract, urinary ways and forms a large part of the iron in the body. The epithelium is divided into different types of origin, structure, and functions.
One type of epithelium - is mesothelioma. He lines the serous membrane, ie, the peritoneum, pleura and lung, pericardium (pericardial sac), etc. Consequently, mesothelioma - a tumor that grows from the mesothelial tissue and affects the serous membranes. Mesothelioma can be benign or malignant (the latter is more common).
Mesothelioma - a rapidly growing aggressive tumor that metastasizes early, treating it rather difficult, especially if you have been diagnosed late. The median survival of patients is 1-2 years.

Mesothelioma is most common lung pleura and peritoneum, at least - of the testicles, joints, pericardium. Among the risk factors that increase the risk of mesothelioma include prolonged exposure to asbestos, especially in combination with smoking. This swelling can sometimes be asymptomatic, but if symptoms do occur, at an early stage can not be considered specific, why mesothelioma is difficult to diagnose. Often it is detected at a late stage, hence the low survival rate of patients with mesothelioma.

Pleural mesothelioma is usually manifested in pain at the bottom of the chest at the back or the side surface, shortness of breath, hoarseness, coughing up blood, swelling of the face and upper extremities, in some cases, may experience difficulty swallowing, cough, weight loss, weakness, sweating, fever (low-grade, but constant). One of the most common symptoms - effusion (fluid in the pleural cavity).

Peritoneal mesothelioma usually has the following symptoms: abdominal pain, nausea, vomiting, weight loss, enlarged abdomen. Some patients have ascites - fluid in the peritoneal cavity. Usually this type of cancer occurs in men over 50.
There are several treatments for malignant mesothelioma. If the patient is in good condition, and the tumor is localized, the possibility of radical surgery, ie, the complete removal of the tumor. If the patient's heavy, and the swelling is extensive, can perform palliative surgery - operation to eliminate or reduce the discomfort caused by tumor growth.

However, as we have said, mesothelioma is often diagnosed at a late stage, when major surgery is impossible to produce because of the serious condition of the patient. In such cases, radiation therapy may be used as the primary method of treatment. Also, after the non-radical operations can be assigned a radiation therapy to kill any remaining cancer cells. And for investment due to the growth of tumors symptoms (shortness of breath, difficulty swallowing, pain, bleeding) use palliative radiation.
Another method of treatment of mesothelioma - chemotherapy, the drugs can enter not only intravenously, but the pleural or peritoneal cavity (depending on whether a tumor - mesothelioma of the pleura or peritoneum mesothelioma). Chemotherapy can be as basic or secondary treatment for cancer (depending on what stage the mesothelioma), but keep in mind that this method of treatment provides only a temporary effect and is used as a palliative.

Despite the fact that mesothelioma - a rare type of tumor that is no reason to neglect their health. Do not ignore any of the warning signs, it's better to be safe than to lose valuable time. There have been cases where the symptoms of mesothelioma took for chronic bronchitis or  smoker's cough , and when they put the correct diagnosis, it was too late. And if you are at risk (in contact with asbestos or production), do not forget about regular checkups with your doctor.

Wednesday, 29 August 2012 00:59

Mesothelioma settlement amounts

These main types of malignant mesothelioma tend to be epithelioid, sarcomatoid as well as mixed / biphasic. Epithelioid one of the general form, since approximately 50-70% of the most reported cases of mesothelioma is usually the view. Epithelioid also offers the best tactical differences. This has an effect on the internal organs and internal treatment floors. Sarcomatoid a much more serious problem, because it has the effect of additional tissue in your body such as the material of cartilage, muscle groups, bone tissue and also fat. However, this particular cancer is much rarer, as it just happens 7-20% of that time period. Mixed / biphasic has equally generated from cancer at the same time, which is 20-35% of the situations.
asbestos settlement occurs within the assembly relative to mineral precipitation in the environment. This provides a remarkable resistance to high temperature. Before many market sectors used asbestos settlement on a huge amount, because it is effective and also robust. This is a study that 80% of cases result from the settlement experience of asbestos. This type of mineral, when exposed to temperatures leaves behind, invade environment. Fiber as a special layer of fabric attached regarding bronchial begin development associated with malignant tissue.
At present, these types of asbestos settlement ends a condition for which is incurable, but because of the amount of attention the disease gets a lot of top scientists and researchers are also all over the world will work to develop an end to the disease. Just like numerous cancer, not continuing assistance as well as attention, research, and the funding is not possible.
For your case is also vital that you provide all of your medical records relating to your mesothelioma prognosis and also the forecast. The more you can offer, the more far away and you and your circumstances are likely to be. This can help maintain the actual monetary award, which really deserves a man, as organizations asbestos settlement will often try to break free from the littlest settlement.
Normal treatment of the disease tends to be radiation therapy, surgery and also rays. It really is preferable to combine several treatment once and for all the results. The disease is identified delayed so many times, surgery can not be solved. With all the latest treatments, such as angiogenesis, gene drug as well as doctors immunotherapy wants to discover some ways to make the patient live longer.
The actual culprit in the city do not automatically fit people. In legal jargon particular defendant is more widely known as the "syndrome." Despite the fact that the great thing can really be the person most of the time it is - an organization, a company, or maybe organization.
Incredible as it might seem, it would be - because the dangers associated with the settlement of asbestos becomes identified earlier - back in the 50's, P. Lorillard Company used a deadly crocidolite fibers in its Kent e cigarette filter systems. The manual evaluation of the list of most craigs identification settle asbestos personal consultant writes about the background loaded asbestos settlement "mikronochnuyu" filter used on Kent tobacco between 1952 and also 1956. And Ough. Reports Web site of the Federal Government S., which anyone who has smoked cigarettes swab each day for Kent, smoking in between 1952 and 1957 may have faced a 131 million crocidolite construction year.
Mediastinum research Mediastinoscopy (area in the upper part of the body, made up of the heart, arteries excellent, lymph nodes, esophagus, nervousness, and so on). Mediastinoscopy can try the lymph nodes in your body to find metastases.
Pathological examination biopsy samples under study is a microscopic lense - the difficulty to identify mesothelioma at some point. Cellular structure of the tumor can be viewed many different types. These types of fabrics may seem similar, along with another cancer. Peritoneal cells may well seem like pleural mesothelioma, or even additional types of lung cancer and also ovarian cancer. Epithelioid type of mesothelioma is much more frequent and better assessed on the treatment of more than aggressive sarcomatous appearance. Biphasic mesothelioma - a combination of each.
Asbestos settlement proposals publicity boiler manufacturer reduced considering the 70th by modifications in isolation and also shelled parts inspection.

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