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Tuesday, 18 December 2012 23:51

Pleural mesothelioma asbestos cancer. Debate


Features of morphological diagnosis of pleural mesothelioma asbestos cancer

Morphological diagnosis of pleural mesothelioma asbestos cancer is difficult, especially in terms of the differential diagnosis of metastatic cancer of the pleura on the breast, lung, kidney, colon, ovary, with pleural synovial sarcoma. The diagnosis is usually set according to the cytology of pleural fluid, thoracoscopy, pleural biopsy.

In difficult cases, immunohistochemical study. Mesothelial cells can be differentiated from fibroblast and epithelial only with electron microscopy and immunophenotyping.

Experience in diagnosis and surgery of pleural mesothelioma asbestos cancer

For 1999-2006 in 14 patients used thoracoscopy, as the final method for diagnosis of pleural mesothelioma asbestos cancer. In the analyzed cases, the results of clinical examination, including the data of morphological studies material transthoracic puncture and pleural fluid is not allowed to establish the morphologic diagnosis. Indications for diagnostic thoracoscopy thus considered tumor on the pleura, hydrothorax unknown etiology. Thoracoscopy was performed by the standard technique, life-threatening complications were observed. Unfortunately, the prevalence of the process - in the form of massive, mostly multiple tumor nodules do not allow radical removal of the tumor.

Endoscopic diffuse mesothelioma asbestos cancer presented merging tumors (benign, white nodes, with patches of yellow or red) that infiltrated thickened visceral and parietal pleura, lung, pericardium, protrudes into the pleural cavity, followed by the presence of sero-fibrinous or hemorrhagic pleural fluid. In all cases, the material obtained by thoracoscopy was sufficient for histological and immunnogistohimichesky study. In one patient, due to the impossibility of operations in VATS mode due to severe obliteration of the pleural space and the inability to create a work space in it, surgery was transformed (the converted) in the thoracotomy. Mean operative time was 38 minutes. Postoperative period in all patients was uneventful. Drain is removed, usually at night II, and their abandonment of a longer term due pronounced accumulation of fluid in 4 (27%) cases. Noted that surgical trauma was not significant: narcotic analgesics were used only for the first night.

Performing diagnostic thoracoscopy in patients with pleural mesothelioma asbestos cancer shows the great benefits of this technology to increase diagnostic capabilities of surgery, along with a decrease in postoperative pain and a shorter stay in hospital. The patient operated on 26 years (03/11/04) in the abdominal compartment RCRC about tumors localized in the left pleural (extrapulmonary adjacent the costal pleura, the size 4h7h7 cm), and in the abdomen (left subphrenic, size 7h11h13 cm). Intraoperative diagnosis of pleural mesothelioma asbestos cancer and peritoneal. Deleted pleural mesothelioma asbestos cancer, with resection of the lower lobe of the left lung and gastrectomy (with pancreatectomy with splenectomy) combined abdomino-thoracic access to the left (Academician M.I.Davydov). Postoperative period without complications. Subsequently, chemotherapy Gemzar and cisplatin. The patient remains under the supervision of the CRC.

Surgery localized mesothelioma asbestos cancer lung and pleura

Authors: Vladimir Shevtsov, Popov M., Kuzmin IV, Chizhov, NV (Moscow Oncological Hospital № 62) Solitary (localized) fibrous tumor (SFD) formerly known as localized (benign) mesothelioma asbestos cancer. described in 1870 E.Wagner. During thoracic lesions in 80% of the tumor based on the visceral leaf, 20% - the parietal and mediastinal. Quite a long time it was thought that the tumor originates from the mesothelial cells. New studies using electron microscopy, immunohistochemistry indicate its mesenchymal origin. For the description of the tumor, the definitions "benign", "reduced", "localized". Also used the term "focal fibrous mesothelioma asbestos cancer." In the international nomenclature, SFO is considered normative.

Localized pleural mesothelioma asbestos cancer occur 3-4 times less common than malignant. Abroad, described hundreds of patients with localized mesothelioma asbestos cancer, in Russia - a few dozen. Age was 50-70 years. Pleural occurs mainly in women. Appearance of the tumor is quite typical. This is a round or oval dense texture formation of 6-20 cm in diameter with a smooth outer surface, covered with a piece of the pleura. Tissue on the cut gray-pink, layered, with foci myxomatosis and, sometimes, small foci of hemorrhage. The tumor may be broad-based, but more often grows in thin connective stalk.

Localized mesothelioma asbestos cancer can reach large sizes but are usually asymptomatic. It is usually detected by X-ray examination of the lungs. Period from identifying tumor before surgery is 3-5 years, but sometimes it lasts 8-20 years.

For 1998-2006 6 patients were operated on the solitary fibrous tumor ("benign" mesothelioma asbestos cancer). This is 0.6% of the operated on for cancer of the lungs and mediastinum. Age of the patients corresponded 43-69 years. Differential diagnosis (using thoracoscopy) was performed with tumors of the lung, mediastinum, and diaphragm.

All patients radically operated. Performed: removal of the tumor in a thoracoscopy, atypical lung resection. Tracked ranged from 3 months to 8 years. Recurrence was observed.

Two observations are of particular practical interest.

The patient received 69 years 02/16/1998, complaining of dry cough, subfertil temperature. Duration - 4 months. Examined at a tuberculosis dispensary, where specific lesion was confirmed. Radiographically in the posteromedial parts of the lower lobe of the left lung was found globular shade up to 5 cm in diameter, clearly defined, relatively homogeneous, lower pole is adjacent to the aperture. Tumor site was far from the mediastinal pleura tyazhistoy portion of lung tissue. The root of the left lung expanded to several small bronchopulmonary lymph nodes. Mediastinum - without features. On fibreoptic, ezofagoduodenoskopii, barium enema and abdominal ultrasound abnormalities were detected. Serum tumor markers: CEA - 4.6 ng / ml, CA 125 - 19.0 U / mL, CYFRA 21-1 - 1-1,8 ng / ml.

Performed thoracoscopy, revealed no pathological changes in the visceral, parietal, slide fragmalnoy and mediastinal pleura. Immediately made thoracotomy 5 intercostal space on the left. Solid tumors up to 6 cm in diameter located in the tenth segment of the lung. Pleura over it is not changed. Connection with mediastinal pleura tumors also were found. Cytology detected punctate tumor lymphoid cells with no signs of malignancy. Performed wedge resection of the lung. Postoperative period without complications.

Histological examination of the diagnosis of the SFO lower lobe of the left lung (the drug concentration sultirovan prof. I.G.Olhovskoy). Patients were examined in 2006 revealed no recurrence. This observation is the first in the Soviet literature, a rare observation intrapulmonary localization solitary mesothelioma asbestos cancer.

Patient 43 years old was admitted to hospital on 10.11.2000 with complaints of weakness, sweating. increase of temperature. When X-rays and CT scans in the projection V segment of the right lung was situated soft tissue tumor size of 1.5 cm in diameter with a clear smooth contours, homogeneous structure. When ezofagogastro-duodenoscopy, bronchoscopy - no pathological changes. Performed thoracoscopy: the parietal pleura tumor up to 2 cm in diameter on the stem, covered with smooth, whitish capsule. In the legs nearby tissues of the chest wall and pleura are not changed. With the power cut by the pleura, indents 2-3 cm of the stem. Tumor was removed. Pathological examination revealed a solitary mesothelioma asbestos cancer.

Pressing is the question of malignant variants of the SFO. According to the literature, they are found in 8 (13.3%) cases and appear invasion into the chest wall, destruction of ribs. Syndrome "drum fingers" was observed only in benign form of the tumor. After surgery systemic symptoms disappeared and came back with recurrence. Histological structure of the recurrence may be quite benign. Therefore, the prognosis of the SFO is always questionable. 10-15% of patients relapse, so the lesion should be removed completely. However, there are cases by removing the SFO "kuskovaniya" with good long-term results. The use of modern diagnostic techniques (computed tomography, the study of tumor markers, thoracoscopy, cytological puncture) to select the correct treatment strategy, as well as an adequate amount of the transaction. Thoracoscopy is a leading method to define the relationship of the tumor and the pleura. For small amounts of tumor thoracoscopic resection is the treatment of choice. If there is doubt in the diagnosis and large-scale education shows a radical operation with VATS support.

Published in Mesothelioma video


Cancer tumor that has developed from the tissue that lines the surface of the chest, abdominal cavity or heart (pericardium) There are three types of malignant mesothelioma: epithelioid, which has the best prognosis, sarcomatoid, and mixed type.

Most of mesothelioma occurs in the chest cavity and are called pleural mesotheliomas. In 10-20% of the tumor develops in the abdominal cavity - mesothelioma of the peritoneum. Pericardial mesothelioma is very rare.

Exposure to asbestos is the major risk factor for mesothelioma. The risk of developing mesothelioma asbestos cancer depends on the intensity and duration of exposure to asbestos. Prolonged contact at a young age greatly increases the risk of mesothelioma. Smoking by itself has no effect on the increase in the incidence of mesothelioma asbestos cancer, but the combination of smoking and asbestos exposure significantly increases the risk of lung cancer.

Tumor for a long time may be asymptomatic and therefore often detected in late stages, which adversely affects the prognosis of the disease. The median survival of patients is usually only 1-2 years.

Early symptoms of mesothelioma are not specific. These patients are often ignored or taken for expression of the usual non-neoplastic diseases. Most patients with mesothelioma asbestos cancer symptoms appear within 2-3 months prior to the detection of the tumor.

In some patients the symptoms can persist for 6 months or more. 50% of patients with pleural mesothelioma noted pain in the chest on the side or the back. Many patients complain of shortness of breath. In some cases, there is difficulty swallowing, cough, sweating, weakness, weight loss and fever. Almost all found pleurisy, fluid in the pleural cavity.

Other symptoms can point to hoarseness, coughing up blood, swelling of the face and upper extremities.

In patients with peritoneal mesothelioma asbestos cancer can be abdominal pain, nausea, vomiting, and weight loss. Some patients may receive the fluid in the abdomen (ascites) and / or swelling.

Treatment of malignant mesothelioma

Surgical treatment of mesothelioma

The operation can be performed as palliative or therapeutic purposes. Under palliative operation meant surgery, with which you can eliminate or reduce pain or discomfort caused by tumor growth- removing the pleura, removal of fluid from the pleural cavity, etc. Such operations are used when it is impossible to remove the tumor because of the prevalence of the process or the serious condition of the patient. Patients in a satisfactory condition, a localized tumor, radical operations, ie complete removal of mesothelioma.

Radiotherapy Mesothelioma

External irradiation in patients with mesothelioma asbestos cancer is used most often. With internal radiation radioactive material is supplied directly to the tumor.

This type of radiation therapy is used as the primary method of treatment for patients in critical condition, when they cannot move a serious operation. Auxiliary radiation therapy is administered after nonradical operations to destroy the remaining cancer cells.

Palliative irradiation is used to relieve symptoms caused by tumor growth: shortness of breath, pain, bleeding and difficulty swallowing.

Mesothelioma Chemotherapy

In the treatment of patients with malignant mesothelioma chemotherapy drugs can be administered not only intravenously, but intrapleural and intraperitoneally (into the abdominal cavity).

Depending on the stage of the tumor, chemotherapy may be as basic or secondary treatment. Moreover, chemotherapy is used only as a palliative, giving only a temporary effect.

Of anticancer drugs used: doxorubicin, cisplatin, methotrexate, vinorelbine, and others in various combinations.

Saturday, 15 September 2012 14:35

What you need to know about cancer?


In the XX century, the cancer is called "disease of the century", and in the XXI is probable that he will be the first scourge of mankind. Grim realities of today - each year from cancer worldwide are killed about seven million people. But even that terrible figure will not limit: by The World Health Organization, approximately 2020 cancer will take the leading position among the causes of death, which will allow him to overtake cardiovascular system.

Bodies, most predisposed to cancer

Scientists argue that the frequency of lesions of various human organs cancer - is different. As for the men, most often (about 50% of all cases of canser), they are defeated the digestive system, then the frequency goes: respiratory organs, skin, mouth, lower lip and throat. In the ladies cancer often affects the uterus, then - the digestive organs, breast, and skin.

Cancer of the digestive system begins with the deterioration of swallowing function, at first only during swallowing coarse food, and in the future, depending on the degree of tumor growth and narrowing of the lumen of the start even when consuming liquid food. Sometimes the pain can be felt in the chest and epigastria region.

Breast cancer (breast cancer) characterized by different forms, but most often it is represented by a solid painless tumor, which is located in the interior of the breast. In most cases, women find it yourself, it is absolutely random. Quite often, it is preceded by little lumpy breasts. If you find something like that, see your doctor as soon as possible!

Cancer of the lower lip begins to develop on the site of a variety of diseases lips - non-healing sores and cracks, stains, and other processes that are associated with the growth of tissue. As practice shows, these sores can be covered crust, simulating the process of healing, but it soon disappears, and ulcers will continue to harden and grow. In order to prevent the formation of cancers in organic diseases of the lower lip as quickly as possible to stop smoking because smoking only assists in the development of malignant tumors.

Uterine cancer, as you might guess from the name, is striking in the first place, the cervix. Its development occurs against a variety of chronic processes (erosion, polyps, etc.). Quite often the cause of this disease is unliquidated damages, which are caused by abortion or childbirth. At the initial stage of cancer of the uterus does not have any external manifestations? They occur only when the tumor starts increasing. This disease is accompanied by a disturbance of menstruation, pain, bleeding. Doctors say that the pain - is one of the last signs, signaling an advanced stage of the disease.

As for colon cancer, it may appear on the background of polyps located in the rectum. His most "popular" is a sign of bleeding, but it appears very late - at a time when the tumor was large development and began to disintegrate. Such bleeding is sometimes confused with hemorrhoids, respectively, the disease starts. It should be noted that the hemorrhoid is not premalignant disease, but they are quite capable of existing together.

Lung cancer or mesothelioma asbestos cancer is beginning to dry cough in the morning and later at night. With the development of tumors, coughing will generate a significant amount of sputum, which has a slimy character. In some cases, there is pain in the chest, which intensified during coughing, shortness of breath and a recurring slight temperature increase, in rare situations - hemoptysis. Please note that a major role in the development of lung cancer is smoking regularly.

Stomach cancer often occurs as a result of suffering a prolonged illness of the stomach - ulcers, polyps, and various forms of gastritis. The primary symptoms are slightly: blanching of the skin, fatigue, weight loss. Later formed an aversion to meat food, begins nausea, vomiting and lost appetite. If the tumor was a good development, periodically may appear painful. It should be noted that the risk of cancer is characterized by the direct dependence of hereditary predisposition.

Stage for cancer

This terrible disease has several stages of development. Depending on what stage the cancer that will take appropriate actions to further diagnosis and treatment. Cancer is characterized by four stages (I, II, III and IV). If there is a small, limited places cancer, then it is about I-th stage of the cancer, and also a lot of advanced metastatic disease, we can talk about cancer IV-th stage.

Depending on the variety of diseases are assigned specific treatment techniques. In the first research professionals only define the clinical picture of the cancer. In the future it is determined whether the cancer can be removed.

Staging, that is the definition of the spread in the human body of the cancer process, is considered the most important event, necessary to select the method of treatment. We should not forget that the process of cancer development may take several years or even decades. During this period, pre-cancerous cells, where under the influence of carcinogens, made genetic changes (mutations), to become more viable and active. In the future, they form something like tumorlet which are clusters of malignant tissue, is not harassing people, and they are almost impossible to diagnose. As a result, tissue grows vessels that feed them, and these tumorlet turns into a malignant tumor of the final stages of development.

Saturday, 15 September 2012 14:26

What is asbestos cancer?

Cancer of the pleura (mesothelioma) - a malignant tumor arising in the pleura or peritoneum. Pleura - a thin serosa surrounding the lungs (visceral or pulmonary pleura, visceral pleura) and the inner surface of the chest (pleura parientalnaya, parietal pleura). Serous membrane has smooth, moist, shiny pleura, thanks to the secretion of a small amount of liquid in it.

Pleura are covered with mesothelium - a single layer of squamous epithelium lining the serous membrane of the vertebrate body. Between parientalnym and visceral pleura is the pleural cavity with a small amount of liquid that reduces friction sheets for respiratory motion of light, so that they can slide over each other without causing pain to the person. Source of cancer pleural mesothelial cells are the origin belonging to the serous membranes of the pleura, peritoneum, pericardium. Mesothelioma asbestos cancer is defined as the primary tumor, more malignant course.

Symptoms of mesothelioma asbestos cancer 

General weakness.

Pain in the chest.

Shortness of breath.

Sometimes purulent fluid in the pleural cavity or grayish mucous expectoration.

Causes of Mesothelioma asbestos cancer 

Usually the cause of mesothelioma is the inhalation of asbestos dust. Asbestos - a fibrous natural mineral consisting essentially of magnesium silicate. Currently asbestos industry used less and less. Hi attempt to replace other materials. When processing or destruction of asbestos turns into asbestos dust that enters the environment. By inhalation of large amounts of asbestos dust or prolonged inhalation of its possible pneumoconiosis, lung cancer or mesothelioma of the pleura or peritoneum. These diseases may occur after 10-30 years. Some health care possible cause of these diseases is considered cigarette smoke containing hazardous substances.

Treatment of mesothelioma asbestos cancer

Stop the growth of the tumor is not possible. You can only alleviate the symptoms of the disease. For example, pain of growing pains in the chest.

In this disease, people, unfortunately, can do nothing to help themselves. It can only be a preventive measure to avoid dust.

When chest pain or difficulty breathing, as soon as possible by a qualified physician.

The doctor will likely try to find the cause of sickness, he carefully examine the patient. Perform a CT scan on which a tumor of the pleura is seen distinctly. Some patients in the pleural cavity accumulates bloody fluid (exudates) or cough up a whitish-gray mucous expectoration. In such cases investigated exudates and sputum. However, mesothelioma asbestos cancer diagnosis is established only after a biopsy of the tissue sample and research. If the disease has arisen due to occupational exposure to asbestos dust, the doctor about it shall notify the competent authorities for the protection of human health.

The disease asbestos cancer

Largely as a result of exposure to asbestos dust cells mesothelium covering the pleura, and part of the connective tissue are transformed into malignant. Formed a malignant tumor that affects the entire pleura. Gradually thickened pleura, thus forming a "shell" that covers all light and prevents it straightened. Difficult breathing movements of light, oxygen supply is broken, then there is a cessation of breathing. The disease is incurable.

Use of asbestos declined in recent years, so the mesothelioma was a rare disease. Today, lung cancer is more common than mesothelioma.

Mesothelioma Prevention

The only way to prevent mesothelioma - no contact with asbestos. Today it is not difficult, because materials, which include asbestos, very little. Almost always used alternative materials. In addition, it is recommended to stop smoking.

Thursday, 06 September 2012 11:04

Mesothelioma asbestos cancer

 

Mesothelioma or asbestos cancer - a form of cancer, which is characterized by the fact that cancer cells are placed in a membrane envelope. Membrane - mezotelium, consists of two layers. Mezotelium produces lubricating fluid, through which bodies are moved safely, such a beating heart.
Mesothelioma asbestos cancer - a disease in which the mezoteliuma cells are abnormal and begin to divide. Modified cells can invade organs and connective tissues, damaging them. Cancer cells often spread to other parts of the body. The disease usually begins in the chest, and then progresses and affects other parts of the body. Major risk factor for the disease is contact with asbestos. The danger is that the pathology is not immediate, but after 30-50 years.
The disease is characterized by low average survival of patients, only 1-2 years. If the disease is detected at later stages, the prognosis is extremely unfavorable. Early symptoms of Mesothelioma asbestos cancer can easily be confused with symptoms of other diseases. Primary symptoms in most patients appear for 2-3 months before detection of the tumor. Asbestos cancer can have some basic varieties: pleural, pericardial, vaginal, and benign mesothelioma of the peritoneum.
· Symptoms of Mesothelioma asbestos cancer
· Symptoms vary depending on the type of mesothelioma. For example, patients with pleural mesothelioma asbestos cancer complain of pain in the chest on the side and the back. Many patients experience shortness of breath. Some cases are characterized by shortness of breath, coughing, sweating, weakness and fever. Other symptoms include: hoarseness, facial swelling, hemoptysis. Peritoneal mesothelioma patients complain of abdominal pain, nausea and vomiting. In some patients, fluid can build up in the abdomen - ascites.
· Aftermath
The main danger of the disease is that the abnormal cells may be spaced throughout the body. There are three main pathways of tumor cells in the human body. Tumor cells through the blood or lymphatic system may spread throughout the body, the result - the formation of secondary tumors. The process of separation of tumor cells is called metastasis. The primary tumor and secondary education are to cancer of the same species. Depending on what stage the disease, mesothelioma asbestos cancer is conventionally divided into two groups. The localized mesothelioma is characterized by the fact that cancer cells are located exclusively in the inner layer of the chest wall in the tissues covering the lungs, diaphragm, and in the bag, which covers the heart, with the same party. To include common mesothelioma disease II, III, IV stage. In the pathological process may also be involved lymph nodes that are on the other side of the chest or even beyond.
· One of the negative effects of mesothelioma is a relapse. Relapse - repeatedly arisen disease after the patient has already been covered treatment. Education may recur in the pleural area or in a new place.
· Treatment and complications
· There are several diagnostic techniques that enable the diagnosis and confirm it. To detect tumors using: X-ray, computed tomography, magnetic resonance imaging, thoracoscopy, laparoscopy.
· To date, identify several basic methods of treatment of mesothelioma asbestos cancer. It should be noted that the standard methods used, so the methods that are currently in clinical trials. The essence of the clinical trials - the improvement of existing therapies, data on new treatments. The possibility of patient participation in clinical trials is discussed with your doctor. The standard method of treatment include: surgical way, radiation and chemotherapy.
· Surgical method involves removal of the tumor by surgery. Even if the doctor removes the visible part of the tumor, the patient will still prescribe postoperative chemotherapy and radiation therapy. This is done in order to completely remove the abnormal cells.
· Radiation therapy is a method of treatment using high-frequency X-ray. This approach allows you to completely remove the cancer cells, slowing tumor growth. Radiation therapy may be of two types: external and internal. External radiation therapy of mesothelioma asbestos cancer involves the direction of the unit, located next to the patient directly to the tumor. Internal therapy suggests that radioactive substances are inserted near the tumor or in the tumor itself. The method of radiation therapy is chosen depending on the stage and type of cancer.
Chemotherapy involves the use of cytotoxic drugs, their action is directed at the destruction of cancer cells, slowing the malignant process. Chemotherapy drugs can be taken orally, intravenously. Drug enters the bloodstream and spreads throughout the body, destroying the tumor cells. If the chemical agent is injected directly into the affected area, such as the peritoneum, such a therapy called regional. Combination chemotherapy involves the use of several drugs. The route of administration is chosen depending on the type and stage of the cancer being treated.
Today, there is the search for new treatments. Information about them is distributed by the National Cancer Institute, as all the necessary information about the programs and opportunities for participation in it can be obtained from your doctor. The success of disease control is correct and timely diagnosis, prescription of adequate and effective treatment.

 

Thursday, 06 September 2012 11:03

What is peritoneal mesothelioma


What triggers mesothelioma of the peritoneum

Pathogenesis (what's going on?) During peritoneal mesothelioma

Symptoms of peritoneal mesothelioma asbestos cancer

Diagnosis of peritoneal mesothelioma

Treatment of peritoneal mesothelioma

Prevention of peritoneal mesothelioma

Which doctors should contact if you have peritoneal mesothelioma

What is peritoneal mesothelioma asbestos cancer:

For prolonged inhalation of asbestos vapors can affect different organs including the peritoneum, which causes mesothelioma peritoneum.

Peritoneal mesothelioma, occurs more frequently in men over 50 years old.

What triggers peritoneal mesothelioma:

Peritoneal mesothelioma is caused by exposure to asbestos body vapors.

Pathogenesis (what's going on?) During peritoneal mesothelioma:

Peritoneal mesothelioma asbestos cancer can grow as a node in a part of the visceral or parietal peritoneum (nodular form) or more diffusely distributed peritoneum, infiltrating it, like sheath enveloping internal organs (diffuse form). If the cavity of the abdomen remains free, then it is observed accumulation of sero-fibrinous or hemorrhagic exudates.

Histologically, the tumor usually has the structure of a solid adenocarcinoma or cancer. In addition, the isolated fibrous, tubular, and mixed form of pleural mesothelioma. Malignant mesothelioma metastasize to regional lymph nodes (96.5%), and other lung and pleura (75%), the pericardium. Hematogenous metastases occur much less frequently.

Symptoms of peritoneal mesothelioma:

The clinical picture of the initial stages of peritoneal mesothelioma asbestos cancer is very fuzzy. The symptoms appear when there is a malfunction of the abdomen as a result of growing into their tumor. The first complaint with mesothelioma of the peritoneum reduced to discomfort and abdominal pain without clear localization, nausea, sometimes poor appetite, alternating diarrhea and constipation. Gradually accumulates in the abdominal cavity fluid with plenty of protein, but not always, containing tumor cells. When a localized form of mesothelioma of the peritoneum in the abdomen may be palpable movable tumor.

Diagnosis of peritoneal mesothelioma:

Diagnosis is the detection of malignant cells in the exudate and biopsy specimens obtained during paracentesis, biopsies or laparotomy.

Treatment of peritoneal mesothelioma:

Treatment of localized forms of mesothelioma, we lay in its radical surgical removal, in diffuse forms of surgical treatment is not indicated, use radiation or chemotherapy, or a combination, therapy is seldom effective.

Prevention of peritoneal mesothelioma:

For prophylaxis (prevention) of mesothelioma asbestos cancer should avoid contact with asbestos at home and at work.

Thursday, 06 September 2012 10:57

Brief description of the disease Mesothelioma

 

Mesothelioma asbestos cancer - it is extremely dangerous type of tumor, characterized by interstitial lung pleura and peritoneum. This tumor is formed mesothelium - the epithelial tissue that lines the surface of the body cavities.
Mesothelioma does not spare neither adults nor children, the swelling can occur even in the 2-year-old kid.
And the risk of disease in men by almost 8 times higher than in women. This is due to several reasons.

Causes of Mesothelioma asbestos cancer

The main cause of cancer - mesothelioma - is long and intensive engagement with asbestos. As you know, asbestos - a building material, a mixture of fiberglass and plaster. Inhalation of asbestos dust can directly cause cancer. Asbestos fibers actively affect the lining of the airways, getting all of them deeper into the pleura. The accumulation of these fibers causes mesothelioma - a professional disease of builders. Smoking aggravates the situation, while not being the main cause of Mesothelioma asbestos cancer.
There are also cases when a genetic predisposition has become a major factor in the development of mesothelioma.

Symptoms of  Mesothelioma asbestos cancer

Early symptoms of pleural mesothelioma include: pain in the chest, weakness, difficulty breathing, dry cough - and many others, the neglect of which will lead to irreversible consequences.
Mesothelioma of the peritoneum, as a rule, it is severe abdominal pain, weakness, vomiting, and weight loss. Few people care about these symptoms: some mistake them for symptoms of poisoning, others openly ignore. Remember that mesothelioma "wait" and will not reveal in 2-3 - months, when the symptoms will show activity: pain increased, and the general condition deteriorates. Since it's still cancer - cancer treatment effective in the early stages.
The fact is that as with any cancer, the peritoneal Mesothelioma asbestos cancer is under development. In the first stage the patient is affected pleura of the lung, lymph nodes at the same time while intact. Peritoneal mesothelioma is the second stage has been a relatively large "field of activity": it extends to the diaphragm. The third stage is characterized by lesions of the lymph nodes and the front of the chest wall. The fourth stage - the most dangerous - and integrated into the surrounding tissue and even carried through the bloodstream to more distant organs, thus affecting the entire body.

Diagnosis of Mesothelioma asbestos cancer

Diagnosis of mesothelioma can be done in different ways:
  • · X-rays will reveal pleural thickening, and the presence of fluid in the pleural cavity
  • · CT (computed tomography) to determine the stage of the tumor and help assign an effective treatment.
  • · With the help of an MRI (magnetic resonance imaging) has become possible to determine whether the diaphragm is intact mesothelioma.
  • · Thoracoscopy - endoscopic method for studying the pleural cavity. Manufactures special machines, reveals a tumor in its earliest stages. As a rule, the study takes a small piece of the pleura or pleural fluid. A similar method of investigation - laparoscopy - used for inspection of the abdominal cavity.
Treatment of Mesothelioma asbestos cancer

Mesothelioma treatment is usually carried out in several ways:
· Chemotherapy. Drugs prescribed for chemotherapy can be administered as an intravenous and intrapleural (or into the abdominal cavity in the treatment of peritoneal mesothelioma). Treatment of tumors with poisons and toxins effectively kills cancer cells, while not causing harm to human body strong.
· Radiation therapy or radiation therapy. Characterized as a highly effective, rapidly destroying the cells in the Mesothelioma asbestos cancer. He has a number of unpleasant side effects: burn tissue, shortness of breath, fatigue, hair loss.
· Surgical method. Mesothelioma Treatment by removal of the tumor / pleura is the most effective, however, not all patients with mesothelioma, it is shown. Only upon satisfactory general condition of the patient and the absence of other diseases permitted surgery. A complete removal of the tumor is possible only if the localized mesothelioma.

Other ways of treating Mesothelioma asbestos cancer.

For example, removal of fluid from the pleural cavity through a needle. After this procedure, there is improvement in the general condition of the patient, reducing the pain. However, over time fluid builds again, and repeats the procedure. Introduction of antibiotics into the pleural cavity also helps to reduce the amount of fluid and pain.
Once diagnosed with mesothelioma, the people, on average, do not live more than a year, with the average age of the cases - 65 years. Think about it and avoid any contact with the deadly substance in his youth, so you do not regret it in old age.

 

At the University Clinic in Frankfurt use an innovative method of chemoembolization in the treatment of complicated cancer - Mesothelioma.


The history of the disease the patient from the UK showed promise of this method: 49-year-old Debbie Bryuver appealed to the Cancer Center, University Hospital of Frankfurt, the deterioration after 2 years of remission-x and got good results.

The cause of cancer in women has been communicating with her father, who worked on the asbestos production and brought home asbestos dust (a major factor in cancer of the pleura). Once a resident of Great Britain won the court the corporation for the production of asbestos and has received a huge financial compensation, and the verdict from the local doctors (British Aesculapius believed that it remained only 6-9 months of life), went to Germany for treatment.

Having regular chemotherapy, Debbie decided to try an innovative technique in the treatment of cancer (usually the method used in the treatment of liver cancer). German doctors have modified the methodology specifically for the patient and the British got a good result - the size of tumors significantly decreased, which ensures the patient a few years of life the patient.

Now a happy Debbie is struggling to this method became available to all cancer patients in the UK.

Chemoembolization - a method of local chemotherapy of malignant tumors of different localization by embolization (closure of the lumen of stopping blood flow) arteries feeding the tumor embolizing material containing anticancer drug. Refers to one of the types of interventions endovascular surgery or interventional radiology.

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